ABSTRACT Intervening proteins, or inteins, are mobile genetic elements that are translated within host polypeptides and removed at the protein level by splicing.In protein splicing, a self-mediated reaction removes the intein, leaving a peptide bond in place.While protein splicing can proceed in the absence of external cofactors, several examples o
BackgroundHIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for Hayward C-Spa XI Parts cardiovascular diseases.We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammatory response through inhibiting endoplasmic reticulum (ER) stress in macrophage
Motor sequences can be learned using an incremental approach by starting with a few elements and then adding more as training evolves (e.g., learning a piano piece); conversely, one can use a global approach and practice the whole sequence in every training session (e.g., shifting gears in an automobile).Yet, the neural correlates associated with s